The School of Medicine of the Università del Piemonte Orientale “Amedeo Avogadro“ combines the Department of Health Sciences (DHS) and the Department of Translational Medicine and is devoted to basic science and translational research in the field of Medicine, in strict collaboration with the top-quality hospital (AOU Maggiore della Carità).
The DHS, is a multi-disciplinary research environment with strong emphasis on both developments of new technologies and clinical translation. The mission of the DHS is to perform cutting edge science in the field of liver diseases, tumor biology, tissue engineering, gene therapy, genetic and immunology and to promote the translation of basic discoveries into therapeutic advances.
Fully equipped labs are available at UPO to perform molecular biology, cell culture, imaging, biochemical assays. Instrument facilities include: BSL2 class laboratory, flow cytometer and ultracentrifuge for Lentiviral vectors (LVs) concentration and confocal microscope. Animal facilities include 5 rooms for rabbit, small and big rodents, 1 for immuno-compromised mice and 2 for animal manipulation and surgery.
More information about UPO can be obtained at the website.
The main tasks of UPO within the project will be the preparation of LVs containing the FVIII gene for the transduction of BOECs from haemophilia A patients (WP2). Moreover, UPO will participate in the characterisation of the FVIII-corrected BOECs concerning their safety potential (WP4) and in vivo implantation in an immunocompromised mouse model of haemophilia A (WP5).